چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | علوم پزشکی کرمانشاه |
| نویسنده | نفر چندم مقاله |
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| هادی خرازی | اول |
| عنوان | متن |
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| کلمات کلیدی | P109C COMPARISON OF CYCLOSPORINE 2-HOUR POST DOSE LEVELS TO TROUGH LEVELS IN STABLE RENAL RECIPIENTS PATIENTS IN WEST IRAN H. Kharrazi: M. Abbasi; D. Raicsi; M. Rezaei Biochemistry Department and Renal Transplant Center of Kermanshail University of Medical Sciences, Kermanshah, Iran Introduction: Changing the method of monitoring cyclosporine (Neoi blood levels with 2 hours post dosing levels (C2) was shown to be m effective than trough levels (CO) in de novo kidney transplant patient, Thisi study examined the feasibility on changing cyclosporine monitoring froil traditional CO to novel C2 levels in our stable renal recipients and compared! their coefficients of variation (CV). Material and Methods: 51 men and 29 women who are stable renall recipients(cngrafted over 6 months) treated with triple (cyclosporinej azathioprine, prednizolon)therapy were compared for 3 months before andl after changing the monitoring strategy in this study. The mean values andl ranges of CO and C2 were presented. The %CV was used to compare tbtl reproducibility of dose corrected CO versus C2 monitoring strategy. Results: During the change of monitoring, all recipient patients had stablfl creatinine, urea and liver function tests, within the 6-month period. The dosage! of cyclosporine was changing in 25(31%) of the 80 patients because C2 level were obviously too high or too low which were not evident with previous C dose monitoring. The mean CO and C2 of our stable renal recipients treated with triple therapjl was 286180.4 and 9141357 ng/ml, and they ranged from 122-467 and fro 375-1964 ng/ml, respectively. The mean %CV of CO monitoring was 17.7 and for C2 24.6 Although thert| is no significant difference between the mean %CV of CO and C2, i though our six month study showed the changing of traditional CO monito level to C2 is much more beneficial for monitoring individual patient mainljl because extreme high or low C2 levels were not reflected by trough dosagtl monitoring. |
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