چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | علوم پزشکی کرمانشاه |
| نویسنده | نفر چندم مقاله |
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| اسد ویسی رایگانی | اول |
| عنوان | متن |
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| کلمات کلیدی | ANALYSIS OF ASSOCIATION BETWEEN APOLIPOPROTEIN E GENOTYPES , THE K VARIANT OF BUTYRYLCHOLINESTERASE (BCHE-K) AND ALZHEIMERS DISEASE (AD)
A Vaisi Ravgani'-2. M Zahrai', A Soltanzadeh',M Doosti', E Javadi1, M Rezaei'
'Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2 Department of Biochemistry, Kermanshah University of Medical Sciences, Iran.
Introduction: Recent studies indicate that there is a synergic association
between butyrylcholinesterase K Variant (BChE-K) and apolipoprotein E e4
(APOE-E4) in risk of Alzheimer's disease (AD), whereas some studies, have
been unable to confirm these findings.
Methods: We decided to conduct a study in 105 Alzheimer patients from
Tehran, Iran and 129 age and sex matched controls test for can association
between BChE-K,APOE-g4,and AD by PCR RFLP methods.
Results indicate that distribution of BChE genotype in AD group shows
significantly differentcompared to thecontrolgroup(X2=12.2,df=2,p=0.002). In
additiotifrequencyofBChE-KalleleinADgroupissigmftcantlylligbercompaied
to control group 24% versus 12% (X2= 20.6,df=2,p |
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| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
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