چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | علوم پزشکی کرمانشاه |
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| اسد ویسی رایگانی | اول |
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| کلمات کلیدی | P8 SCREENING OF BUTYRYLCHOLINESTERASE (BCHE) GENOTYPE IN ORDER TO EVALUATE THE RISK OF PROLONGED APNEA AFTER SUCCINYLCHOLINE ADMINISTRATION A Vaisi Raygani,', H Rahi', AA Vaisi Raygani1 1 Department of Biochemistry, Faculty of Medicine, Kermanshah University of Medical Sciences, Iran. Introduction: Assay of serum BChE has several applications such as, diagnosis of intoxication with organophosphorous insecticides, neural affecting gases (war gases) and hepatic disease. In addition, determination of BChE genotypes and frequency is important. The individuals bearing abnormal genes of BChE may develop prolonged apnea after they receive succinylcholine. Therefore, frequencies of BChE genotypes determine special genotypes of BChE susceptibility to succinylcholine for evaluation of risk of I prolonged apnea after receiving succinylcholine. We determined the BChl genotype frequency and risk of apnea after administration of succinylcliolim in an Iranian population (Kermanshah). Methods: we examined the frequency of BChE genotypes in 1553 volunteers and apparently healthy people from the Kermanshah population, measurements of total BChE activity and percent of inhibition by dibucaine (dibucaine number DN), fluoride (FN) and Ro2 (Ro2N) are helpful in genotyping of individuals. SPSS was used for the statistical analysis. Results: Reference range for serum total BChE activity was 4.6-16.5 U/ffll (butyrylthiocholinelodide was substrate).The mean value for men (9.03) was significantly (p<0.05) higher than women (8.55U/ml). The frequency of four allele U,A,F,S were calculated as BChElU=0.9826, BChElA=0.01867, BChE 1 F=0.00934, BChE 1 S=0.00161. The frequency genotypes of BChE for UU, UA US UF and AA AF AS FF SS are 94.829%, 4.443% and 0.78% respectively. Conclusion: Our study showed that in comparison with other studies lie populations in west Iran (Kermanshah) can be considered as a population nit high frequency of abnormal variants of BChE. Therefore, the measuremenl of BChE activity and genotyping would be advisable for any one who isle receive the muscle relaxant(succinylcholine). |
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