چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | علوم پزشکی کرمانشاه |
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| اسد ویسی رایگانی | اول |
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| کلمات کلیدی | LAMI-003 Association between Apolipoprotein E Polymorphism in Coronary Artery Disease Patients in Kermanshah Population, in West of Iran Kharrazi, H.1*, Vaisi Raygani, A 1. Sabokroh, A.R. 1, and Pourmotabedd, T. 2 iDepartment of Medical Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran and 2 Department of Molecular Sciences, University of Memphis, Health Sciences, Memphis, TN Objective: Coronary artery disease (CAD) is the major cause of death in developing countries, such as Iran. Apolipoprotein E(APOE) gene(e2,e3,e4) is considered an important genetic determinant of CAD. The aim of this study was to investigate the relationship between ApoE polymorphism with lipid variation in CAD patients in Kermanshah, Iran. Methods: This case-control study consisted of 115 CAD patients who angiographically had at least 30% stenosis and 135 unrelated controls. ApoE polymorphism was detected by PCR-RFLP methods. Results: The ApoE-e4 allele frequency was significantly higher in the CAD group than in controls(18.7%versus 3.3%,p<0.001). The odds ratio(ORs) for CAD in individuals with e4 allele was 10.2(95%CI=4.8-21.6,p<0.001). ORs for e2 allele was found to be 3.4 (95%CI =1.6-7.6,p=0.01). The genotype frequencies for e2, e3, and e4 alleles in control group were 4.1%, 92.6%, and 3.3%, respectively. LDL-C level was significantly higher (p<0.001) in CAD patients compared with the control group. Conclusions: ApoE-e4 allele is a risk factor for CAD, so that carrier of this allele with high level of LDL-C may be susceptible to CAD and myocardial infraction. KEY WORDS: APOE; Coronary artery disease; genetic polymorphism; genetic risk factor; lipid profile; variants; Kermanshah Iran. |
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