چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 6392 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease |
| نوع مقاله | مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی | ISI |
| سطح مقاله | |
| IF | 8.303 |
| عنوان نشریه | NEUROLOGY |
| نوع نشریه | خارجی ایندکس شده |
| شماره نشریه | Print ISSN: 0028-3878 |
| دوره | 84(19) |
| تاریخ انتشار شمسی | 1394/02/22 |
| تاریخ انتشار میلادی | 2015 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.neurology.org/content/84/19/1956.short |
| DOI | 10.1212/WNL.0000000000001575. Epub 2015 Apr 15. |
| آدرس علمی (Affiliation) نویسنده متقاضی | Sleep Disorders Research Center (M.T.), Kermanshah University of Medical Sciences, Iran |
| Objectives: Based on the hippocampus disconnection hypothesis in Alzheimer disease (AD), which postulates that uncoupling from cortical inputs contributes to disinhibition-like changes in hippocampus activity, we suggested that in patients with AD, the more the intrinsic functional connectivity between hippocampus and precuneus is decreased, the higher hippocampal glucose metabolism will be. Methods: Forty patients with mild AD dementia, 21 patients with mild cognitive impairment, and 26 healthy controls underwent simultaneous PET/MRI measurements on an integrated PET/MR scanner. 18F-fluorodeoxyglucose-PET was used to measure local glucose metabolism as proxy for neural activity, and resting-state functional MRI with seed-based functional connectivity analysis was performed to measure intrinsic functional connectivity as proxy for neural coupling. Group comparisons and correlation analysis were corrected for effects of regional atrophy, partial volume effect, age, and sex. Results: In both patient groups, intrinsic connectivity between hippocampus and precuneus was significantly reduced. Moreover, in both patient groups, glucose metabolism was reduced in the precuneus (AD < mild cognitive impairment < controls) while unchanged in the hippocampus. Critically, the lower connectivity between hippocampus and precuneus was in patients with AD dementia, the higher was hippocampus metabolism. Conclusion: Results provide evidence that in patients with AD dementia, stronger decrease of intrinsic connectivity between hippocampus and precuneus is linked with higher intrahippocampal metabolism (probably reflecting higher neuronal activity). These data support the hippocampus disconnection hypothesis, i.e., uncoupling from cortical inputs may contribute to disinhibition-like changes of hippocampal activity with potentially adverse consequences on both intrahippocampal physiology and clinical outcome. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| مسعود طهماسیان | اول | بلي |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Tahmasian-Neurology-2015.pdf | 1394/02/29 | 415413 | دانلود |
| Screen Shot 2015-05-19 at 09.03.26.png | 1394/02/29 | 22625 | دانلود |
