Effects of Levothyroxine Treatment on Lipid Profile in Subclinical Hypothyroidism: A Randomized Clinical Trial
نویسندگان: فرید نجفی , کتایون درخشنده , مهرعلی رحیمی , کارون شاه ابراهیمی , طاهره کلانتریان , رزیتا ناصری , اعظم شریفی
کلمات کلیدی: Levothyroxine, subclinical hypothyroidism, Cholesterol, lipoprotein-A, LDL, HDL
نشریه: Galen Medical Journal , 2 , 4 , 2015
| کد مقاله |
6813 |
| عنوان فارسی مقاله |
|
| عنوان لاتین مقاله |
Effects of Levothyroxine Treatment on Lipid Profile in Subclinical Hypothyroidism: A Randomized Clinical Trial |
| نوع مقاله |
مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی |
ISI |
| سطح مقاله |
هیچکدام |
| IF |
|
| عنوان نشریه |
Galen Medical Journal |
| نوع نشریه |
داخلی ایندکس شده |
| شماره نشریه |
2 |
| دوره |
4 |
| تاریخ انتشار شمسی |
1394/03/12 |
| تاریخ انتشار میلادی |
2015 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
http://www.gmj.ir/gmj/index.php/gmj/article/view/214 |
| DOI |
|
| آدرس علمی (Affiliation) نویسنده متقاضی |
Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| Introduction: Studies demonstrated contravercial results on subclinical hypothyroidism (SCH) regarding lipid profile alternation with or without levothyroxine treatment. The purpose of this study is to investigate the effect of Levothyroxine on the serum lipids in SCH Method: One-hundred patients with SCH referred to the Taleghani hospital in Kermanshah were recruited and randomly assigned into the intervention or control group. The patients in the intervention group received levothyroxine, 50-75 microgram for three months. The patients in the control group received the same placebo with the same dose and duration. Lipid profile was measured before and after the trial and the changes were compared between groups. (IRCT code: 138903244179N1) Results: Triglyceride, Total Cholesterol, LDL, HDL and Lipoprotein-A was measured, before and after the treatment. None of the factors showed significant difference either between of within groups, before and after the treatment (p<0.05). Conclusion: Treating with levothyroxine does not have any clinically significant impact on lipid profile in SCH patients, which indicates that we should not expect SCH patients to use levothyroxine solely for lipid profile alternation, except those with other clinical indication for treatment. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| pdf article.pdf | 1394/05/20 | 399223 | دانلود |