چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 8302 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Meta-analysis of studies comparing adjuvant dexamethasone to glycerol to improve clinical outcome of bacterial meningitis |
| نوع مقاله | مروری (Review) |
| بالاترین نمایه نامه بینالمللی | ISI |
| سطح مقاله | |
| IF | 0.812 |
| عنوان نشریه | J RES MED SCI |
| نوع نشریه | داخلی ایندکس شده |
| شماره نشریه | 2 |
| دوره | 21 |
| تاریخ انتشار شمسی | 1395/01/20 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://jrms.mui.ac.ir/index.php/jrms/article/view/10422 |
| DOI | |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Infectious and Tropical Disease, School of Medicine, 1Department of Biostatistics and Epidemiology, School of Public Health, |
| Background: Neurological complications are a problematic factor in acute bacterial meningitis; hence, its prevention is the key to ensure the success of meningitis treatment. Glycerol and dexamethasone are both applied in this regard. Oral glycerol is an appropriate alternative instead of intravenous dexamethasone because it does not have problems related to intravenous injection, the high cost, and drug complications. The main objective of this study was to compare the efficacy of adjuvant dexamethasone versus glycerol in order to improve the clinical outcome of bacterial meningitis. Materials and Methods: We conducted a search on the available resources including PubMed, Ovid, Elsevier, Cochrane, and another search engines such as Google till 2014. All clinical trials that were performed in the field of comparing the effectiveness of the two drugs and met the inclusion criteria were gathered and after extraction the relative risk (RR) values, the pooled RR was calculated. The main outcome was neurological complications. Meta-analysis of the data was performed in Stata version 11.2 using both fixed and random effect models, weighting each study by inverse of variance. Results: In 5 comparative studies (1,340 patients), the rate of neurological complications of glycerol compared to that of dexamethasone was 1.02 [95% confidence interval (CI), 0.98 compared to 1.12]. The rate of neurological complications of dexamethasone compared to dexamethasone + glycerol was 1 (95% CI, 0.97 compared to 1.03), dexamethasone compared to placebo was 0.99 (95% CI, 0.97 compared to 1.03), glycerol compared to glycerol + dexamethasone was 0.98 (95% CI, 0.94 compared to 1.02), and glycerol compared to placebo was 0.97 (95% CI, 0.94 compared to 1.01). In these studies, no difference was reported between dexamethasone and glycerol in terms of reducing neurological complications. Conclusion: Although there were some weak evidences for the nonstatistical significant effect of glycerol in the prevention of neurologic complication after meningitis, there was no difference between glycerol and dexamethasone. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| بابک صیاد | سوم | خير |
| کیقباد قدیری | چهارم | خير |
| فیض اله منصوری | دوم | خير |
| فرید نجفی | هفتم | بلي |
| سیاوش وزیری | اول | خير |
| منصور رضایی | ششم | خير |
| الهام ترکاشوند | پنجم | خير |
| محسن عزیزی | هشتم | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 10422-39320-1-PB.pdf | 1395/02/18 | 1322836 | دانلود |
