چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 8403 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Synthesis and cytotoxicity evaluation of some new 6-nitro derivatives of thiazole-containing 4-(3H)-quinazolinone |
| نوع مقاله | مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی | ISI |
| سطح مقاله | |
| IF | |
| عنوان نشریه | Research in Pharmaceutical Sciences |
| نوع نشریه | داخلی ایندکس شده |
| شماره نشریه | 3 |
| دوره | 11 |
| تاریخ انتشار شمسی | 1395/02/11 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://rps.mui.ac.ir/index.php/jrps/issue/view/45 |
| DOI | |
| آدرس علمی (Affiliation) نویسنده متقاضی | 2Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran. |
| Quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. Thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. Due to valuable cytotoxic effects of both thiazole groups and quinazoline derivatives, in this study a series of quinazolinone-thiazole hybrids were synthesized and evaluated for their cytotoxic effects on three cell lines including MCF-7, HT-29, and PC-3. Among tested compounds (quinazolinones and three intermediates), k5 and k6 showed highest cytotoxic activities against PC3 cell line. K6 and C were most active compounds against MCF7 and K6 showed best cytotoxicity on HT-29 cell line. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| علیرضا علی آبادی | دوم | خير |
| لیلا حسین زاده | اول | خير |
| مرضیه رحمانی خواجویی | پنجم | بلي |
| مسعود کلانتری | سوم | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1691-3821-1-PB.pdf | 1395/03/01 | 113809 | دانلود |
