چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 8791 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Safety and efficacy of Intraurethral Mitomycin C Hydrogel for prevention of post- traumatic anterior urethraltricture recurrence after internal urethrotomy |
| نوع مقاله | مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی | pubmed |
| سطح مقاله | |
| IF | |
| عنوان نشریه | Journal of Injury & Violence Research |
| نوع نشریه | داخلی ایندکس شده |
| شماره نشریه | 2 |
| دوره | 8 |
| تاریخ انتشار شمسی | 1395/04/11 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://jivresearch.org/jivr/index.php/jivr/article/view/812/543 |
| DOI | 10.5249/ jivr. v8i2.812 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Mahmoudreza Moradi: Department of Urology, Imam Reza Hospital, Kermanshah University of Medical Science s , Kermanshah, Iran. Tel: +98(83)34282670. Email: drmrmoradi@gmail.com |
| Background: Evaluation of the safety and efficacy of intraurethral Mitomycin C (MMC) hydrogel for prevention of post - traumatic anterior urethral stricture recurrence after internal urethrotomy. Methods: A thermoresponsive hydrogel base consisting of 0.8 mg MMC with 1cc water and propylene glycol to PF - 127 poloxamer was used in theater. 4 0 male patients with short, non - obliterated, urethral stricture were randomized into 2 groups: control and MMC. After internal urethrotomy, the MMC group patients received the MMC - Hydrogel while the others were just catheterized. Both groups had their c atheters for at least 1 week. After surgery, they were followed up by means of medical history and physical examination, monitoring voiding patterns and retrograde urethrogram at 1 month, 6 months and 1 year after surgery . Results: 40 male patients between 14 to 89 years old (Mean = 54.15) underwent internal urethrotomy. The average age for the control and MMC group was 54.55±21.25 and 53.75±24.75 respectively. In a comparison of age between the two groups, they were matched (P=0.574) . Stricture length was 10.7±5.9 and 9.55±4.15 mm for the control and MMC group respectively. There were no statistically meaningful differences between the two groups (P=0.485) . Fifteen patients had a history of one previous internal urethrotomy which in a comparison between the two groups meant there was no meaningful difference (P=0.327) . During postoperative follow up, total urethral stricture recurrence happened in 12 patients: 10 patients (50%) in control group and 2 patients (10%) in MMC group. The differenc e was stat istically significant (P=0.001) . There were no significant complications associated with the MMC injection in our patients. Conclusions: Based on our results, MMC Hydrogel may have an anti - fibrotic action preventing post - traumatic anterior urethral stricture recurrence with no side effects on pre - urethral tissue. Due to our study limitations, our follow up time and the small number of patients, our results were not conclusive and further studies will be needed with a longer follow up time |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| محمودرضا مرادی | اول | بلي |
| کتایون درخشنده | دوم | خير |
| بابک کریمیان | سوم | خير |
| مهتاب فصیحی | چهارم | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 812-7314-3-PB.pdf | 1395/05/13 | 292804 | دانلود |
