چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 9662 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine |
| نوع مقاله | مروری (Review) |
| بالاترین نمایه نامه بینالمللی | pubmed |
| سطح مقاله | هیچکدام |
| IF | |
| عنوان نشریه | International Journal of Hematology-Oncology and Stem Cell Research |
| نوع نشریه | داخلی ایندکس شده |
| شماره نشریه | 1 |
| دوره | 11 |
| تاریخ انتشار شمسی | 1395/10/12 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/554 |
| DOI | |
| آدرس علمی (Affiliation) نویسنده متقاضی | Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| Mesenchymal stem cells (MSCs), as major stem cells for cell therapy, have been studied from different aspects in preclinical and clinical settings for more than a decade. These cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. Hence, they could be used in regenerative medicine, tissue engineering and immune therapy. MSCs-based therapy have been recently used for treatment of cancer regarding the migratory potential of these cells towards tumor cells which makes them considerable candidates, also for cell therapy in both allogeneic and autologous settings. So, this review attempts to focus on the factors secreted by MSCs such as cytokines, their functional role in mounting and controlling immune responses mediated by different immune cell subpopulations and their significance in regenerative medicine in clinical trials. Although, further studies remain to be done to increase our knowledge of regulating development mechanisms, homeostasis and tissue repair in order to provide new tools to implement the efficacy of cell therapy trials. Although MSCs have been proved safe and effective for cell therapy, there are still challenges to overcome before widely applying MSCs in clinic. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| کامران منصوری | نهم | خير |
| یحیی پاسدارخشکناب | هشتم | خير |
| احمد تاجه میری | چهارم | خير |
| رقیه حسینی کیا | اول | خير |
| محبوبه حسینی کیا | پنجم | خير |
| فرهاد کیان آرا | ششم | بلي |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IJHOSCR-11.1.pdf | 1395/10/05 | 1002809 | دانلود |
