چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 9976 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Immunotoxins in cancer therapy: Review and update |
| نوع مقاله | مروری (Review) |
| بالاترین نمایه نامه بینالمللی | ISI |
| سطح مقاله | از مجلات برتر25%(scopus-Q1) |
| IF | 3.279 |
| عنوان نشریه | International Reviews of Immunology |
| نوع نشریه | خارجی ایندکس شده |
| شماره نشریه | 4 |
| دوره | 36 |
| تاریخ انتشار شمسی | 1396/04/13 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.ncbi.nlm.nih.gov/pubmed/28282218 |
| DOI | doi.org/10.1080/08830185.2017.1284211 |
| آدرس علمی (Affiliation) نویسنده متقاضی | aDepartment of Medical Laboratory Sciences, School of Paramedicine, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| Immunotoxins are a novel class of cancer therapeutics that contains a cytotoxic agent fused to a targeting moiety. Various toxic agents fromdifferent sources are used in immunotoxin development, including bacterial, plant and human origin cytotoxic elements. Although bacterial and plant-derived toxins are highly toxic and commonly used in immunotoxins, their immunogenicity for human restricted their application in cancer therapy. Here, we discuss the advantages and limitations of bacterial toxins such as Pseudomonas and Diphtheria toxins, plant toxins such as ricin and gelonin, and some endogenous protein of human origin such as RNases and Granzymes. This article will also review different generations of immunotoxinswith special focus on immunotoxinswhich are under clinical trials or approved for clinical use. Finally, current deimmunization strategies for development of new lessimmunogenic recombinant immunotoxins will be discussed. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| بهمن اکبری | اول | خير |
| حسن داریوش نژاد | ششم | خير |
| فاطمه صفری | چهارم | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Immunotoxins in cancer therapy Review and update.pdf | 1395/12/18 | 1019338 | دانلود |
