چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 10295 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Enhanced sublingual immunotherapy by TAT-fused recombinant allergen in a murine rhinitis model |
| نوع مقاله | مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی | ISI |
| سطح مقاله | هیچکدام |
| IF | 2.551 |
| عنوان نشریه | International Immunopharmacology |
| نوع نشریه | خارجی ایندکس شده |
| شماره نشریه | |
| دوره | 48 |
| تاریخ انتشار شمسی | 1396/04/10 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.ncbi.nlm.nih.gov/pubmed/28501765 |
| DOI | doi: 10.1016/j.intimp.2017.04.011 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| Allergen-specific sublingual immunotherapy (SLIT) is well known as an effective and non-invasive route to induce allergy desensitization. The goal of this study was to investigate whether a TAT-fused recombinant allergen could enhance SLIT efficacy. BALB/c mice sensitized to the main allergen (Che a 3) of Chenopodium album pollen were treated sublingually either with rChe a 3 (100 μg/dose) or rTAT-Che a 3 (100 μg/dose), two times per week for eight weeks. SLIT with rTAT-Che a 3 led to significantly greater allergen-specific IgG2a than rChe a 3; however, neither rTAT-Che a 3 nor rChe a 3 affected allergen-specific IgE or IgG1 antibody levels. In addition, interleukin 4 (IL-4) levels in re-stimulated splenocytes from the rTAT-Che a 3 mice were significantly lower than in those from the rChe a 3 mice, while interferon-γ (IFN-γ) was significantly greater in the rChe a 3 mice than in the rTAT-Che a 3 mice. Furthermore, sublingual administration of rTAT-Che a 3 induced significantly greater TGF-β secretion in re-stimulated splenocytes than administration of rChe a 3. Accordingly, SLIT with rTAT-Che a 3 led to significantly greater expression of TGF-β- and Foxp3-specific mRNAs in the splenocytes than in those from the rChe a 3 mice. Our findings demonstrate that TAT-fused rChe a 3 suppressed the allergic response through preferential enhancement of systemic regulatory T-cell (Treg)-mediated immunity responses, likely by facilitating allergen capture and presentation by sublingual Langerhans-like dendritic cells. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| فرهاد سالاری | اول | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Enhanced sublingual immunotherapy by TAT-fused recombinant allergen in.pdf | 1396/03/13 | 1644253 | دانلود |
