چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 10450 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Ethyl acetate fraction of Allium hirtifolium improves functional parameters of isolated hearts of diabetic rats |
| نوع مقاله | مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی | ISI |
| سطح مقاله | هیچکدام |
| IF | 1.19 |
| عنوان نشریه | The Anatolian Journal of Cardiology |
| نوع نشریه | خارجی ایندکس شده |
| شماره نشریه | 6 |
| دوره | 17 |
| تاریخ انتشار شمسی | 1396/03/27 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.journalagent.com/anatoljcardiol/pdfs/AJC_17_6_452_459.pdf |
| DOI | |
| آدرس علمی (Affiliation) نویسنده متقاضی | Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| Objective: Allium hirtifolium (Persian shallot) has a hypoglycemic effect on diabetic animals. The aim of this study was to assess the effect of the ethyl acetate fraction of Allium hirtifolium on the function of isolated hearts of diabetic rats. Methods: The control and diabetic animals were randomly divided into four groups: saline- or extract-treated controls (n=10 and n=6, respectively) and saline- or extract-treated diabetic rats (n=8 and n=9, respectively), which received normal saline or extract for four weeks by daily gavage. The hearts were perfused according to the Langendorff method. Cardiac function parameters, including left ventricular developed pressure (LVDP), heart rate (HR), rate pressure product (RPP; LVDP×HR), and dp/dt were measured. Results: The findings of this study showed that in the extract-treated diabetic rats, LVDP (94.5±9.1 mm Hg, mean±SEM), HR (249±15 beats/min), RPP (22732±1246) and +dp/dt (2598±230) at the baseline were significantly higher than those in the saline-treated diabetic animals, (71.5±4.0), (189±6), (13923±984), and (1701±124), respectively. Furthermore, RPP and HR were also significantly higher than the corresponding values obtained in the saline-treated diabetic rats after ischemia. Conclusion: Besides blood glucose lowering action, oral administration of the ethyl acetate fraction of Allium hirtifolium significantly improved the baseline and post-ischemic cardiac function parameters in streptozotocin-induced diabetic rats. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| علی مصطفایی | پنجم | خير |
| داریوش شکیبایی | چهارم | خير |
| علی اشرف گودینی | سوم | خير |
| مهوش حصاری | دوم | بلي |
| سارا خالقی | اول | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| shallot paper 2017.pdf | 1396/04/11 | 1317645 | دانلود |
| Letter.docx | 1396/04/11 | 11222 | دانلود |
