چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 10519 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | High performance liquid chromatographic determination of azithromycin in serum using fluorescence detection and its application in human pharmacokinetic studies |
| نوع مقاله | گزارش کوتاه (Policy Brife,Short Communication, Short Report, Brief report) |
| بالاترین نمایه نامه بینالمللی | ISI |
| سطح مقاله | هیچکدام |
| IF | 2.603 |
| عنوان نشریه | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES |
| نوع نشریه | خارجی ایندکس شده |
| شماره نشریه | 2 |
| دوره | 823 |
| تاریخ انتشار شمسی | 1384/06/15 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.sciencedirect.com/science/article/pii/S1570023205002047 |
| DOI | |
| آدرس علمی (Affiliation) نویسنده متقاضی | School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| Afast and sensitive high-performance liquid chromatographic method for determination of azithromycin in human serum using fluorescence detection was developed. The drug and an internal standard (clarithromycin) were extracted from serum using n-hexan and subjected to precolumn derivatization with 9-fluorenylmethyl chloroformate as labeling agent. Analysis was performed on a phenyl packing material column with sodium phosphate buffer containing 2 ml/l triethylamine (pH 5.9) and methanol (29:71, v/v) as the mobile phase. The standard curve was linear over the range of 10–500 ng/ml of azithromycin in human serum. The means between-days precision were from 13.3% (for 10 ng/ml) to 2% (500 ng/ml) and the within-day precision from 11.9 to 1.7% determined on spiked samples. The accuracy of the method was 100.7–107.2% (between days) and 100.3–107.8% (within day). The limit of quantification was 10 ng/ml. This method was applied in a bioequivalence study of four different azithromycin preparations in 12 healthy volunteers. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| غلامرضا بهرامی | اول | بلي |
| امیر کیانی | سوم | خير |
| بهاره محمدی | چهارم | خير |
| شهلا میرزایی | دوم | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 10519.pdf | 1396/04/21 | 98010 | دانلود |
