Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol
نویسندگان: توحید جعفری کشکی
کلمات کلیدی: 5-Fluorouracil cream, clobetasol, Erbium YAG laser, trial, vitiligo
نشریه: Journal of Cosmetic Dermatology , 2 , 17 ,
| کد مقاله |
10598 |
| عنوان فارسی مقاله |
|
| عنوان لاتین مقاله |
Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol |
| نوع مقاله |
مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی |
ISI |
| سطح مقاله |
هیچکدام |
| IF |
1.764 |
| عنوان نشریه |
Journal of Cosmetic Dermatology |
| نوع نشریه |
خارجی ایندکس شده |
| شماره نشریه |
2 |
| دوره |
17 |
| تاریخ انتشار شمسی |
1397/01/12 |
| تاریخ انتشار میلادی |
|
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.12373 |
| DOI |
|
| آدرس علمی (Affiliation) نویسنده متقاضی |
Department of Biostatistics, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| Summary Background: Vitiligo is a pigmentary disorder of skin affecting at least 1% of the world population of all races in both sexes. Its importance is mainly due to subse- quent social and psychological problems rather than clinical complications. Various treatment choices are available for vitiligo; however, laser-based courses have shown to give more acceptable results. Objective: The aim of this trial was to evaluate the efficacy of Er:YAG laser as a supplementary medicine to topical 5FU and clobetasol in vitiligo patients. Methods: Two comparable vitiligo patches from 38 eligible patients were random- ized to receive topical 5FU and clobetasol in control group and additional Er:YAG laser in intervention group. Major outcomes of interest were the size of patch and pigmentation score at randomization and 2 and 4 months after therapy. Results: Final sample included 18 (47%) male patients and age of 35.66 8.04. The performance Er:YAG group was superior in all sites. Reduction in the size of patches was greater in Er:YAG group (p-value = .004). Also, this group showed a higher pigmentation scores in the trial period than control group (p-value < .001). Conclusions: Greater reduction in the size and increase in pigmentation score was seen in Er:YAG group especially for short periods after therapy and repeating laser sessions may help improving final outcomes. Er:AYG could help in reducing compli- cations of long-term topical treatments, achieving faster response, and improving patient adherence. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| Mokhtari_et_al-2018-Journal_of_Cosmetic_Dermatology.pdf | 1397/01/08 | 493657 | دانلود |