Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol


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علوم پزشکی کرمانشاه
علوم پزشکی کرمانشاه

نویسندگان: توحید جعفری کشکی

کلمات کلیدی: 5-Fluorouracil cream, clobetasol, Erbium YAG laser, trial, vitiligo

نشریه: Journal of Cosmetic Dermatology , 2 , 17 ,

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کد مقاله 10598
عنوان فارسی مقاله
عنوان لاتین مقاله Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol
نوع مقاله مقاله اصیل (پژوهشی، Original)
بالاترین نمایه نامه بین‌المللی ISI
سطح مقاله هیچکدام
IF 1.764
عنوان نشریه Journal of Cosmetic Dermatology
نوع نشریه خارجی ایندکس شده
شماره نشریه 2
دوره 17
تاریخ انتشار شمسی 1397/01/12
تاریخ انتشار میلادی
آدرس لینک مقاله/ همایش در شبکه اینترنت https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.12373
DOI
آدرس علمی (Affiliation) نویسنده متقاضی Department of Biostatistics, Kermanshah University of Medical Sciences, Kermanshah, Iran

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Summary Background: Vitiligo is a pigmentary disorder of skin affecting at least 1% of the world population of all races in both sexes. Its importance is mainly due to subse- quent social and psychological problems rather than clinical complications. Various treatment choices are available for vitiligo; however, laser-based courses have shown to give more acceptable results. Objective: The aim of this trial was to evaluate the efficacy of Er:YAG laser as a supplementary medicine to topical 5FU and clobetasol in vitiligo patients. Methods: Two comparable vitiligo patches from 38 eligible patients were random- ized to receive topical 5FU and clobetasol in control group and additional Er:YAG laser in intervention group. Major outcomes of interest were the size of patch and pigmentation score at randomization and 2 and 4 months after therapy. Results: Final sample included 18 (47%) male patients and age of 35.66  8.04. The performance Er:YAG group was superior in all sites. Reduction in the size of patches was greater in Er:YAG group (p-value = .004). Also, this group showed a higher pigmentation scores in the trial period than control group (p-value < .001). Conclusions: Greater reduction in the size and increase in pigmentation score was seen in Er:YAG group especially for short periods after therapy and repeating laser sessions may help improving final outcomes. Er:AYG could help in reducing compli- cations of long-term topical treatments, achieving faster response, and improving patient adherence.

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نویسنده نفر چندم مقاله نویسنده مسئول
توحید جعفری کشکیچهارمخير

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