چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 10667 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Evaluation of GeneXpert MTB/RIF for determination of rifampicin resistance among new tuberculosis cases in west and northwest Iran |
| نوع مقاله | مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی | pubmed |
| سطح مقاله | هیچکدام |
| IF | |
| عنوان نشریه | New Microbes and New Infections |
| نوع نشریه | خارجی ایندکس شده |
| شماره نشریه | |
| دوره | 19 |
| تاریخ انتشار شمسی | 1396/06/10 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.sciencedirect.com/science/article/pii/S2052297517300586 |
| DOI | |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| Despite Mycobacterium tuberculosis (M. tuberculosis) control program and anti tuberculosis drugs, DR-TB is one of the most serious public Health issues worldwide. Rapid laboratory diagnosis of M. tuberculosis is needed for the diagnosis of MDR-TB and to find the optimal treatment protocol. The purpose of this study was to detect resistance to RIF in new TB cases susceptible of M. tuberculosis using GeneXpert MTB/RIF assay and standard proportional method in west and north-west of Iran. In this descriptive cross-sectional study, sputum samples were enrolled and screened for M. tuberculosis using Ziehl-Neelsen stain and mycobacterial culture. Smear-positive TB cases were cultured on Lowenstein-Jensen (LJ) medium; afterwards, the presence of resistance to RIF was examined by GeneXpert MTB/RIF and standard proportional method. A total of 400 new cases susceptible of TB were collected, 162 (40.5%) of which were smear and culture-positive for M. tuberculosis. The frequencies of RIF resistance in new smear-positive TB cases were 3.1% and 4.3% for GeneXpert and standard proportional method, respectively. Sensitivity and specificity of GeneXpert were 71% and 100% respectively, compared to that of the proportional method. GeneXpert can be a quick and helpful method for the diagnosis of RIF resistant TB in regions with high rates of DR-TB or MDR-TB. GeneXpert MTB-RIF assay must be used as an early diagnostic method whose results must be confirmed by the standard proportional method. GeneXpert and proportional method complement but do not replace each other. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| سیدحمید مدنی | چهارم | خير |
| پرویز مهاجری | ششم | بلي |
| بابک ایزدی | دوم | خير |
| سارا آتشی | اول | خير |
| عباس فراهانی | پنجم | خير |
| سمیه جلیلیان | سوم | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Atashi-2017.pdf | 1396/05/18 | 96802 | دانلود |
