چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | علوم پزشکی کرمانشاه |
| نویسنده | نفر چندم مقاله |
|---|---|
| لیلا بهبود | دوم |
| شیفته ملک حسینی | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | drug delivery system, Hydrocortisone, Dextran-PLGA micelles |
| چکیده | Hydrocortisone is a glucocorticoid that it’s pharmacological actions are Immunosuppressive, Vasoconstrictive, Anti inflammatory and Anti proliferative effects[1]. Poor water solubility is the defect of this drug. Polymers incorporated with therapeutics can be bioactive to provide their own therapeutic benefit or biodegradable to improve release kinetics and prevent carrier accumulation[2]. By synthesis the micelles composed of Dextran-PLGA copolymer and incorporating Hydrocortisone into them, it is expected that Hydrocortisone bonds to Hydrophobic PLGA in core of the micelle and Dextran as a Hydrophilic polymer on the surface of the micelle leads to dissolution of micelle in body’s fluids and causes the micelles to pass the reticuloendothelial systems. PLGA is biocompatible and biodegradable, exhibits a wide range of errosion time, has tunable mechanical properties and most importantly, is a FDA approved polymer[2]. Dextran is a biocompatible and Hydrophilic polymer which is safe for use in drug delivery systems. |
| متن مقاله | Introduction and Background: Hydrocortisone is a glucocorticoid that it’s pharmacological actions are Immunosuppressive, Vasoconstrictive, Anti inflammatory and Anti proliferative effects[1]. Poor water solubility is the defect of this drug. Polymers incorporated with therapeutics can be bioactive to provide their own therapeutic benefit or biodegradable to improve release kinetics and prevent carrier accumulation[2]. By synthesis the micelles composed of Dextran-PLGA copolymer and incorporating Hydrocortisone into them, it is expected that Hydrocortisone bonds to Hydrophobic PLGA in core of the micelle and Dextran as a Hydrophilic polymer on the surface of the micelle leads to dissolution of micelle in body’s fluids and causes the micelles to pass the reticuloendothelial systems. PLGA is biocompatible and biodegradable, exhibits a wide range of errosion time, has tunable mechanical properties and most importantly, is a FDA approved polymer[2]. Dextran is a biocompatible and Hydrophilic polymer which is safe for use in drug delivery systems. Methods: Dextran-PLGA copolymer incorporating Hydrocortisone was synthesised to make polymeric micelles for drug delivery. Physicochemical properties of fabricated system evaluated with FT-IR and TEM and critical micelle concentration of fabricated system determined. Results: Polymeric micelles was spherical and smaller than 300 nm with appropriate size distribution. Chemical bonding of Dextran-PLGA confirmed with FT-IR and critical micelle concentration of polymer for micelles was 50 g/ml. Discussion and Conclusion: Dextran-PLGA polymeric micelles incorporating Hydrocortisone are promising vehicles for drug delivery. Keywords: drug delivery system, Hydrocortisone, Dextran-PLGA micelles. References: 1. Hughes, J. and M. Rustin, Corticosteroids. Clinics in dermatology, 1997. 15(5): p. 715-721. 2. Liechty, W.B., et al., Polymers for drug delivery systems. Annu Rev Chem Biomol Eng, 2010. 1: p. 149-73. 3. Jeong, Y.I., K.C. Choi, and C.E. Song, Doxorubicin release from core-shell type nanoparticles of poly(DL-lactide-co-glycolide)-grafted dextran. Arch Pharm Res, 2006. 29(8): p. 712-9. |
| نتیجه مقاله | particle size was influenced by various formulations and processing parameters. By optimizing these parameters, dextran-PLGA copolymer micelles with particle daiameter around 252 nm could be produced. Dextran-PLGA polymeric micelles incorporating Hydrocortisone are promising vehicles for drug delivery. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
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| 20180311_140054.jpg | 1396/12/20 | 5665791 | دانلود |
