چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 11897 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | The effect of disease modifying anti-rheumatic drugs (DMARDS) in combination with Prednisolone on TNF-Alfa plasma levels and disease activity in rheumatoid arthritis patients |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | چهاردهمین کنگره بین المللی ایمونولوژی و آلرژی |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | ایران |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1397 |
| سال انتشار/ارائه میلادی | 2018 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1397/02/06 الی 1397/02/08 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://icia.ir/Page/WelcomeMessages |
| آدرس علمی (Affiliation) نویسنده متقاضی | 4.0000 |
| نویسنده | نفر چندم مقاله |
|---|---|
| سیروس جلیلی | سوم |
| مهدی تقدسی | چهارم |
| بهاره کاردیده | دوم |
| زهرا صمیمی | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Rheumatoid Arthritis, DMARD, Disease activity score, TNF-α |
| چکیده | |
| متن مقاله | Background: Rheumatoid Arthritis (RA) is an inflammatory autoimmune disease that leads to destruction of joints and adjacent tissue. Several inflammatory cytokines such as tumor necrosis factor-α (TNF-α) have critical roles in RA pathogenesis. Disease Modifying Anti-Rheumatic Drugs (DMARDs) are the main stay of therapy in treatment of RA. The aim of this study was to assess the plasma levels of TNF-α between three groups untreated, undertreatment patients and healthy subjects and also evaluate the effect of DMARDs on the plasma levels of TNF-α and severity of RA disease. Methods: Peripheral Blood was obtained from three groups including 30 untreated, 30 undertreatment patients and 30 age- and sex-matched healthy subjects. Undertreatment patients were received combinational DMARDs therapy including Methotrexate, Hydroxychloroquine plus Prednisolone. The plasma levels of TNF-α in three groups were measured by ELISA technique. The disease severity was assessed by disease activity score (DAS-28) and patients based on DAS-28 were categorized in four different groups including remission, low, moderate and high disease activity. Results: The plasma levels of TNF-α had no significant difference between three groups (p<0.05) but the DAS-28 was significantly higher In untreated group in comparison with undertreatment group (p<0.01). DAS-28 was significantly correlated with TNF-α level in untreated patients (p=0.01, r=0.549) but we did not see significant correlation between DAS-28 and TNF-α in undertreatment group (p=0.12, r=-0.29). |
| نتیجه مقاله | Conclusion: It can be concluded that the plasma leves of TNF-α could be good predictor of disease activity in RA patiens but quantification of its levels in plasma is not a good biomarker for diagnosis of RA. DMARDs therapy dose not effect on the endocrine levels of TNF-α but it may affect local production of TNF-α. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Reward request.pdf | 1397/02/23 | 91982 | دانلود |
| Picture1.jpg | 1397/03/10 | 130566 | دانلود |
| 34950-2018021911-ysc3656rlh.pdf | 1397/02/11 | 66574 | دانلود |
| samimi.pptx | 1397/02/11 | 427209 | دانلود |
