چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 11898 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Increased autophagy in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis patients |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | چهاردهمین کنگره بین المللی ایمونولوژی و آلرژی |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | ایران |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1397 |
| سال انتشار/ارائه میلادی | 2018 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1397/02/06 الی 1397/02/08 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://icia.ir/Page/WelcomeMessages |
| آدرس علمی (Affiliation) نویسنده متقاضی | 5.0000 |
| نویسنده | نفر چندم مقاله |
|---|---|
| حمید رضا محمدی مطلق | چهارم |
| مونا صادق الوعد | پنجم |
| مهدی تقدسی | دوم |
| بهاره کاردیده | اول |
| زهرا صمیمی | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | , Rheumatoid Arthritis, Autoimmune Disease, Autophagy related genes |
| چکیده | |
| متن مقاله | Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily affects the joints. During RA, T cells and other immune cells recruite to the synovial tissue and promote RA. Autophagy is a process in which intracellular organelles and compounds are degraded and their products are reused by cells. Autophagy as a regulator of cell homeostasis can affect immune cells activation and contribute in RA pathogenesis. The aim of this study was to evaluate the autophagy-related genes (Atgs) expression in two groups of RA patients and healthy persons. Methods: Peripheral Blood was obtained from three groups of donors including 20 patients with early RA, 20 undertreatment RA patients (with Metoterxate, Hydroxychloroquine and Prednisolone therapy) and 20 age- and sex-matched healthy persons. The expression of three autophagy related genes including Lc3b (microtubule associated Light chain 3b), Beclin-1 and Atg5 was investigated by Real time PCR technique. Results: The expression of Atgs was significantly increased in patients with early RA compared to healthy persons. The expression of these genes in undertreatment patients was significantly lower than early RA patients. |
| نتیجه مقاله | Conclusion: This study showed that in early RA patients, the increased expression of Atgs can promote RA pathogenesis. In the other Words our findings suggest that the decreased autophagy can reduce RA severity. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate .pdf | 1397/02/11 | 1323931 | دانلود |
| Presentation Kardideh.pptx | 1397/02/11 | 573794 | دانلود |
| darkhast padash.pdf | 1397/02/24 | 34804 | دانلود |
| IMG_20180514_101644_072.jpg | 1397/02/24 | 221476 | دانلود |
| IMG-20180514-WA0000.jpg | 1397/02/24 | 39754 | دانلود |
| abstract.pdf | 1397/02/24 | 30336 | دانلود |
