چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 12349 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Targeting ubiquitin-proteasome pathway by natural, in particular polyphenols, anticancer agents: Lessons learned from clinical trials |
| نوع مقاله | مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی | ISI |
| سطح مقاله | از مجلات برتر25%(scopus-Q1) |
| IF | 6.491 |
| عنوان نشریه | Cancer Letters |
| نوع نشریه | خارجی ایندکس شده |
| شماره نشریه | |
| دوره | 434 |
| تاریخ انتشار شمسی | 1397/07/09 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.sciencedirect.com/science/article/pii/S0304383518304762 |
| DOI | |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| The ubiquitin-proteasome pathway (UPP) is the main non-lysosomal proteolytic system responsible for degradation of most intracellular proteins, specifically damaged and regulatory proteins. The UPP is implicated in all aspects of the cellular metabolic networks including physiological or pathological conditions. Alterations in the components of the UPP can lead to stabilization of oncoproteins or augmented degradation of tumour suppressor favouring cancer appearance and progression. Polyphenols are natural compounds that can modulate proteasome activity or the expression of proteasome subunits. All together and due to the pleiotropic functions of UPP, there is a great interest in this proteasome system as a promising therapeutic target for the development of novel anti-cancer drugs. In the present review, the main features of the UPP and its implication in cancer development and progression are described, highlighting the importance of bioactive polyphenols that target the UPP as potential anti-cancer agents. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| سمیرا شیرویی | سیزدهم | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1-s2.0-S0304383518304762-main.pdf | 1397/05/04 | 1151974 | دانلود |
