چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 12369 |
| عنوان فارسی مقاله | |
| عنوان لاتین مقاله | Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration? |
| نوع مقاله | مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی | ISI |
| سطح مقاله | از مجلات برتر10%(scopus-Q1) |
| IF | 4.897 |
| عنوان نشریه | Pharmacological Research |
| نوع نشریه | خارجی ایندکس شده |
| شماره نشریه | |
| دوره | 135 |
| تاریخ انتشار شمسی | 1397/06/10 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.sciencedirect.com/science/article/pii/S1043661818305310 |
| DOI | |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| Neurodegenerative diseases (NDs) such as Parkinson's (PD), Alzheimer's (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) cause significant world-wide morbidity and mortality. To date, there is no drug of cure for these, mostly age-related diseases, although approaches in delaying the pathology and/or giving patients some symptomatic relief have been adopted for the last few decades. Various studies in recent years have shown the beneficial effects of omega-3 poly unsaturated fatty acids (PUFAs) through diverse mechanisms including anti-inflammatory effects. This review now assesses the potential of this class of compounds in NDs therapy through specific action against the mammalian target of rapamycin (mTOR) signaling pathway. The role of mTOR in neurodegenerative diseases and targeted therapies by PUFAs are discussed. |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| سمیرا شیرویی | اول | خير |
| سید فاضل نبوی | دوم | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1-s2.0-S1043661818305310-main.pdf | 1397/05/07 | 1072339 | دانلود |
