The predictive roles of obesity and serum vitamin D levels
in body response to hepatitis B vaccine

Moludi, Jalal

اطلاعات کلی مقاله

کد مقاله	13152
عنوان فارسی مقاله	The predictive roles of obesity and serum vitamin D levels in body response to hepatitis B vaccine
عنوان لاتین مقاله	The predictive roles of obesity and serum vitamin D levels in body response to hepatitis B vaccine
نوع مقاله	مقاله اصیل (پژوهشی، Original)
بالاترین نمایه نامه بین‌المللی	ISI
سطح مقاله	هیچکدام
IF	0.323
عنوان نشریه	Progress in Nutrition
نوع نشریه	خارجی ایندکس شده
شماره نشریه	2
دوره	20
تاریخ انتشار شمسی	1397/05/10
تاریخ انتشار میلادی
آدرس لینک مقاله/ همایش در شبکه اینترنت	http://mattioli1885journals.com/index.php/progressinnutrition/article/view/5664/4322
DOI
آدرس علمی (Affiliation) نویسنده متقاضی	department of Nutrition, Faculty of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran

خلاصه مقاله

ackground: Hepatitis B vaccination is the most successful way to prevent the virus infection. Serum concentration of vitamin D has recently been proposed as a novel predictor of response to antiviral treatment in chronic hepatitis infection. Objectives: This study aimed to verify whether the relationship between obesity, serum levels of vitamin D and TNF- α, after immunization with hepatitis B vaccine, plays a role in predicting the rates of antibody titer. Methods: The present study included 45 men and women aged 20 to 50 years old who were assigned in following two groups based on BMI: (A) normal weight and (B) overweight or obese subjects. Both groups received Hepatitis B vaccine in three dozes at; 0, 1, 2 month intervals. Then, Linear Regression analysis was used to evaluate the relationship between serum vitamin D levels and antibody titers. Results: A total number of 45 patients (30 males and 15 females) with a mean age of 35.765±6.63 years were studied. There was a significant difference shown in the mean of vitamin D (P= 0.013) and TNF-α (P= 0.469) between the two groups. Linear regression analysis revealed a significantly lower HBSAg among only female participants with overweight or obesity (P= 0.015). Serum vitamin D level was a main predictor of body response to hepatitis B vaccine and 1 ng/ml increase in serum vitamin D level was associated with a rise of 8.77 IU/mL in HBSAg levels. Conclusions: In our study, after adjusting of other factors, serum vitamin D level was a main predictor of body response to hepatitis B vaccine. Moreover, our study revealed an association between vitamin D deficiency and poor body response to vaccination in obese patients.

نویسندگان

نویسنده	نفر چندم مقاله	نویسنده مسئول
جلال مولودی	دوم	خير

لینک دانلود مقاله

نام فایل	تاریخ درج فایل	اندازه فایل	دانلود
5664-Article Text-19726-3-10-20181212.pdf	1397/10/14	387145	دانلود

The predictive roles of obesity and serum vitamin D levels in body response to hepatitis B vaccine