چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | علوم پزشکی کرمانشاه |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد حسین فرزایی | پنجم |
| امین ایران پناه | اول |
| فاطمه پرویزی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Colorectal cancer, anthocyanins, Natural product, cellular signaling pathways, natural dietary supplement |
| چکیده | Introduction and background: Colorectal cancer (CRC) is one of the most common cancers worldwide. Epidemiological and experimental studies have shown that there is a critical link between inflammatory bowel disease (IBD) and the development of CRC, and the main cause of mortality in patients with IBD is colitis-associated cancer. It was widely proved that compounds derived from plants are effective against CRC such as anthocyanins, which have been reported to possess the anticarinogenesis effect. This review intended to cover the current scientific literature that would support the use of anthocyanins in prevention and treatment of IBD associated CRC, based on well-established studies that have shown the efficacy of these compounds in different experimental models and represents data on possible mechanisms that may be involved in their beneficial effects. Methods: Electronic databases including “PubMed”, “Scopus”, and “Cochrane library” were searched with the keywords “inflammatory bowel disease”, and “colorectal cancer” or “IBD”, and “colorectal cancer” in title/abstract, along with “anthocyanin”, or “anthocyanidin”, or “phytochemical”, or “plant”, or “herb” in the whole text. Data were collected from the inception date until March 2018. Only English language papers were included. Results from primary search were reviewed by two independent investigators. From 6229 results, finally, 61 articles were included in this review. Results: Results from current review have reported the potential effects of anthocyanins including strawberry, cocoa, diospyros kaki phenolic, black raspberry, and Blueberry husks for the prevention of inflammatory induced oncogenesis. Mounting evidence reported that anthocyanins perform their protective role on inflammatory-induced colorectal cancer via different cellular transduction signaling pathways, including inflammatory transcription factors, SAPK/JNK and p38 MAPK cascade, JAK/STAT signaling, NFkB/ pERK/MAPK, Wnt signaling pathway, Nrf2 cytoprotective pathway as well as AMPK pathway and autophagy. Discussion and Conclusion: Combination of anthocyanin-enriched dietary supplements with existing medications can provide new therapy options for IBD associated CRC patients. It should be mentioned that all of anthocyanin enriched extracts contain a significant amount of other non-anthocyanin phenolics (flavonoids and/or phenolic acids) and maybe other non-polyphenolic compounds which have the potential impact in preventive and therapeutic effects of anthocyanins in IBD associated CRC patients. Further, well-designed RCTs are essential to evaluate the role of anthocyanin-enriched medicinal foods as well as isolated anthocyanin components as promising preventive and therapeutic dietary agents for IBD and its associated oncogenesis. Moreover, present review unveiled that more in vitro and preclinical investigations are compulsory to find the absorption, metabolism, bioavailability, bioefficacy, and cellular mechanisms of natural anthocyanins. Keywords: Colorectal cancer, anthocyanins, Natural product, cellular signaling pathways, natural dietary supplement |
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