Opinion: "High-dose immunosuppression to prevent death after paraquat self-poisoning"- under estimation of a significant effect with small mortality rate reduction


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نویسندگان: بیتا انوری

کلمات کلیدی: Management; Paraquat; Treatment; immunosuppression; intoxication; toxicity.

نشریه: Current Rheumatology Reviews , , ,

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کد مقاله 18715
عنوان فارسی مقاله
عنوان لاتین مقاله Opinion: "High-dose immunosuppression to prevent death after paraquat self-poisoning"- under estimation of a significant effect with small mortality rate reduction
نوع مقاله نامه به سردبیر (Letter to Editor, Author Reply )
بالاترین نمایه نامه بین‌المللی pubmed
سطح مقاله هیچکدام
IF
عنوان نشریه Current Rheumatology Reviews
نوع نشریه خارجی ایندکس شده
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دوره
تاریخ انتشار شمسی 1402/03/15
تاریخ انتشار میلادی
آدرس لینک مقاله/ همایش در شبکه اینترنت https://pubmed.ncbi.nlm.nih.gov/36125830/
DOI 10.2174/1573397118666220823155018
آدرس علمی (Affiliation) نویسنده متقاضی

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A randomised double blinded clinical trial about high dose immunosuppression in Paraquat self-poisoning was published by Professor I. Gawaramanna et al. Before their research it seems that a little overestimation might be present in the small previous non randomised clinical trials. This new valuable work clarified the previous exaggerated favourable response to immunosuppression in paraquat self-poisoning, however their analysis underestimated the favourable response to high dose immunosuppression. According to their results, high dose immunosuppression could decrease mortality considering serum paraquat level and effect time of immunosuppressive drugs but the opposite is concluded. They did not mention to the impact of incomplete sample size on their results. Severe paraquat self-poisoning seems to be unresponsive to any treatment and these patients should be analyzed separately according to serum paraquat level. So after reanalysis of their results, the findings seem to be in favour of immunosuppression benefit in paraquat-self poisoning.

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بیتا انوریاولبلي

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