چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی کرمانشاه |
| کد مقاله | 20296 |
| عنوان فارسی مقاله | بررسی اثرات محافظتی و درمانی گیاه کاشمه (گلپر کوهستانی) در کولیت القا شده توسط استیک اسید در رت |
| عنوان لاتین مقاله | Evaluation of the Protective and Healing Effects of Heracleum lasiopetalum Boiss on a Modified Acetic Acid-Induced Ulcerative Colitis Model in Rats |
| نوع مقاله | مقاله اصیل (پژوهشی، Original) |
| بالاترین نمایه نامه بینالمللی | ISI |
| سطح مقاله | هیچکدام |
| IF | 1.0 |
| عنوان نشریه | مجله علمی پزشکی جندی شاپور |
| نوع نشریه | داخلی ایندکس شده |
| شماره نشریه | |
| دوره | |
| تاریخ انتشار شمسی | 1403/02/16 |
| تاریخ انتشار میلادی | |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://brieflands.com/articles/jjnpp-143801 |
| DOI | |
| آدرس علمی (Affiliation) نویسنده متقاضی |
| Background: Ulcerative colitis (UC), a chronic inflammatory condition of the colon with no definitive cure, necessitates the exploration of innovative therapies. Herbal remedies combined with conventional drugs may offer complementary benefits, enhancing treatment outcomes. Objectives: This study investigates the therapeutic effects of Heracleum lasiopetalum Boiss in a rat model of acetic acid-induced UC. Methods: Forty-eight adult female Wistar rats were randomly allocated to six groups (n = 8 per group) for each of two experiments. UC was induced by intracolonic administration of 1 ml of 4% acetic acid for 10 minutes. In the treatment groups, female rats received an oral gavage of 5%, 10%, and 40% aqueous plant extract, sulfasalazine (100 mg/kg), and distilled water for 6 days, starting 3 days after acetic acid administration. The protective groups received substances via oral gavage from 7 days before to 3 days after acetic acid administration. The extent of mucosal ulcers, hyperemia, inflammation, and mucosal bleeding was evaluated based on the Gerald Classification System Score (Macroscopic). Pathological assessment was conducted on prepared slides using the modified Wallace method (Microscopic). Changes in body and colon weight, along with food and water intake, were examined. Results: Significant changes in |
| نویسنده | نفر چندم مقاله | نویسنده مسئول |
|---|---|---|
| سیدحمید مدنی | ششم | خير |
| غلامرضا بهرامی | دوم | خير |
| سیدشهرام میرآقایی | سوم | خير |
| محمد حسین فرزایی | هفتم | بلي |
| حسین ملکشاهی | اول | خير |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| archive(4).zip | 1403/06/28 | 1345825 | دانلود |
